Chen Fengling

Chen Fengling

Dr. Fengling Chen is an associate professor at the College of Biological Sciences, China Agricultural University. Chen Lab was launched in 2024.12 and focused on combining “wet” and “dry” skills to explore early embryo gene regulation.

Chen Lab

Welcome to Chen Lab at China Agricultural University.

We are interested in applying statistical or machine-learning methods in genetic and epigenetic studies. Currently, We mainly focus on
1) developing novel statistical methods to analyze and explore multi-omic data including single-cell omics data, as well as
2) using molecular biology, genomics, and bioinformatics methods to explore gene regulation networks in early embryo development.

News

  • 2024.12. Chen lab officially launched.
  • 2024.12. Welcome Zijun Cheng to join the lab!

Members

Zijun Cheng
Research assistant
M.Phil. Student, SAU. (2021.9-2024.6)
Haochen Zhong
Co-mentor students
B.Sc., Tsinghua U. (2021.9-)

Previous Works

Peer-reviewed papers

- ZGA regulators -
 
OBOX regulates murine zygotic genome activation and early development
Ji, S.*, Chen, F.*, Stein, P.*, Wang, J.*, Zhou, Z.*, Wang, L.*, … & Xie, W.#
Nature, 2023 [Paper]
 
Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation
Nie, X.*, Xu, Q.*, Xu, C.*, Chen, F.*, Wang, Q., Qin, D., … & Li, L.
Nature communications, 2023 [Paper]
- 3D genome methods -
 
HiCDB: a sensitive and robust method for detecting contact domain boundaries
Chen, F.*, Li, G.*, Zhang, M. Q., & Chen, Y.
Nucleic acids research, 2018 [Paper][RCode][MatlabCode]
- 3D genome in differention and disease -
 
MyoD is a 3D genome structure organizer for muscle cell identity
Wang, R.*, Chen, F.*, Chen, Q.*, Wan, X.*, … & Zhu, D.
Nature communications, 2022 [Paper]
 
3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia.
Yang, L.*, Chen, F.*, Zhu, H.*, Chen, Y., … & Wu, H.
Nature communications, 2021 [Paper]