Fengling Chen 陈凤玲

Postdoctoral scholar
MOE Key Laboratory of Bioinformatics, School of Life Sciences,
Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

Academic Interests

I have broad interests in applying statistical or machine learning methods in genetic and epigenetic studies. Currently, I mainly focus on
1) developing novel statistical methods to analyze and explore the epigenetic data, as well as
2) experimental design and integration analysis to explore key regulators in early embryo development.

Education

2020.09~Now Postdoctoral scholar

Department of Life Sciences, Tsinghua University, China

Supervisor: Prof. Wei Xie

2019.07~2020.01 Research Scholar

Department of Statistics, Stanford University, USA

Supervisor: Prof. Wing Hung Wong

2015.09~2020.08 Ph.D. Student

Department of Automation, Tsinghua University

Supervisor: Prof. Michael Zhang & Dr. Yang Chen

2011.09~2015.07 B.S.

Department of Electronic and Information Engineering

Beihang University, Beijing.

Experience

• 2020.12: invited talks at the 7th International Symposium on 3D Genomics, Beijing
• 2018.10: invited talks at the 5th International Symposium on 3D Genomics, Wuhan, Hubei
• 2017.09: top 10 winner out of 368 teams in Mobike Big Data Challenge 2017. View our solution at github.
• 2016.09 - 2017.01: Teaching assistant, Statistical Methods with Applications.

Publications

Peer-reviewed papers (as lead author)

	OBOX regulates murine zygotic genome activation and early development Ji, S.*, Chen, F.*, Stein, P.*, Wang, J.*, Zhou, Z.*, Wang, L.*, … & Xie, W.# Nature, 2023 [Paper]
	Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation Nie, X.*, Xu, Q.*, Xu, C.*, Chen, F.*, Wang, Q., Qin, D., … & Li, L. Nature communications, 2023 [Paper]

HiCDB: a sensitive and robust method for detecting contact domain boundaries Chen, F.*, Li, G.*, Zhang, M. Q., & Chen, Y. Nucleic acids research, 2018 [Paper][RCode][MatlabCode]

	MyoD is a 3D genome structure organizer for muscle cell identity Wang, R.*, Chen, F.*, Chen, Q.*, Wan, X.*, … & Zhu, D. Nature communications, 2022 [Paper]
	3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia. Yang, L.*, Chen, F.*, Zhu, H.*, Chen, Y., … & Wu, H. Nature communications, 2021 [Paper]