Chen Lab

Welcome to Chen Lab at China Agricultural University.

We are interested in applying bioinformatics or machine-learning methods in genetic and epigenetic studies. Currently, We mainly focus on
1) using molecular biology, genomics, and bioinformatics methods to explore gene regulation networks in early embryo development. 2) developing novel statistical or machine-learning methods to analyze and explore multi-omic data including single-cell omics data.

We warmly welcome both wet and dry lab students and postdocs to join the lab！

News

• 2024.12. Chen lab officially launched.
• 2024.12. Welcome Zijun Cheng to join the lab!
• 2025.09. Welcome Rongkai Lv, Ziyu An, Wenhui Lv to join the lab!

Members

Rongkai Lv

Ph.D. Student, CAU. (2025.9-)

M.Phil., HMU. (2022.9-2025.6)

Ziyu An

Ph.D. Student, CAU. (2025.9-)

B.Sc., CAU. (2021.9-2025.6)

Ziyu An

Ph.D. Student, CAU. (2025.9-)

B.Sc., XYNU. (2021.9-2025.6)

Zijun Cheng

Research assistant

M.Phil. Student, SAU. (2021.9-2024.6)

Haochen Zhong

Co-mentor students

B.Sc., Tsinghua U. (2021.9-)

Previous Works

Peer-reviewed papers

	OBOX regulates murine zygotic genome activation and early development Ji, S.*, Chen, F.*, Stein, P.*, Wang, J.*, Zhou, Z.*, Wang, L.*, … & Xie, W.# Nature, 2023 [Paper]
	Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation Nie, X.*, Xu, Q.*, Xu, C.*, Chen, F.*, Wang, Q., Qin, D., … & Li, L. Nature communications, 2023 [Paper]

HiCDB: a sensitive and robust method for detecting contact domain boundaries Chen, F.*, Li, G.*, Zhang, M. Q., & Chen, Y. Nucleic acids research, 2018 [Paper][RCode][MatlabCode]

	MyoD is a 3D genome structure organizer for muscle cell identity Wang, R.*, Chen, F.*, Chen, Q.*, Wan, X.*, … & Zhu, D. Nature communications, 2022 [Paper]
	3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia. Yang, L.*, Chen, F.*, Zhu, H.*, Chen, Y., … & Wu, H. Nature communications, 2021 [Paper]