Fengling Chen 陈凤玲

Postdoctoral scholar
MOE Key Laboratory of Bioinformatics, School of Life Sciences,
Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

Academic Interests

I have broad interests in applying statistical or machine learning methods in genetic and epigenetic studies. Currently, I mainly focus on
1) developing novel statistical methods to analyze and explore the epigenetic data, as well as
2) experimental design and integration analysis to explore key regulators in early embryo development.


2020.09~Now Postdoctoral scholar
Department of Life Sciences, Tsinghua University, China
Supervisor: Prof. Wei Xie
2019.07~2020.01 Research Scholar
Department of Statistics, Stanford University, USA
Supervisor: Prof. Wing Hung Wong
2015.09~2020.08 Ph.D. Student
Department of Automation, Tsinghua University
Supervisor: Prof. Michael Zhang & Dr. Yang Chen
2011.09~2015.07 B.S.
Department of Electronic and Information Engineering
Beihang University, Beijing.


  • 2020.12: invited talks at the 7th International Symposium on 3D Genomics, Beijing
  • 2018.10: invited talks at the 5th International Symposium on 3D Genomics, Wuhan, Hubei
  • 2017.09: top 10 winner out of 368 teams in Mobike Big Data Challenge 2017. View our solution at github.
  • 2016.09 - 2017.01: Teaching assistant, Statistical Methods with Applications.


Peer-reviewed papers (as lead author)

- ZGA regulators -
OBOX regulates murine zygotic genome activation and early development
Ji, S.*, Chen, F.*, Stein, P.*, Wang, J.*, Zhou, Z.*, Wang, L.*, … & Xie, W.#
Nature, 2023 [Paper]
Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation
Nie, X.*, Xu, Q.*, Xu, C.*, Chen, F.*, Wang, Q., Qin, D., … & Li, L.
Nature communications, 2023 [Paper]
- 3D genome methods -
HiCDB: a sensitive and robust method for detecting contact domain boundaries
Chen, F.*, Li, G.*, Zhang, M. Q., & Chen, Y.
Nucleic acids research, 2018 [Paper][RCode][MatlabCode]
- 3D genome in differention and disease -
MyoD is a 3D genome structure organizer for muscle cell identity
Wang, R.*, Chen, F.*, Chen, Q.*, Wan, X.*, … & Zhu, D.
Nature communications, 2022 [Paper]
3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia.
Yang, L.*, Chen, F.*, Zhu, H.*, Chen, Y., … & Wu, H.
Nature communications, 2021 [Paper]