Chen Fengling

Chen Fengling

Dr. Fengling Chen is an associate professor at the College of Biological Sciences, China Agricultural University. Chen Lab was launched in 2024.12 and focused on combining “wet” and “dry” skills to explore early embryo gene regulation.

Research

🎯 Recent Achievements

Peer-reviewed papers

- ZGA regulators -
 
OBOX regulates murine zygotic genome activation and early development
Ji, S.*, Chen, F.*, Stein, P.*, Wang, J.*, Zhou, Z.*, Wang, L.*, … & Xie, W.#
Nature, 2023 [Paper]
 
Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation
Nie, X.*, Xu, Q.*, Xu, C.*, Chen, F.*, Wang, Q., Qin, D., … & Li, L.
Nature communications, 2023 [Paper]
- 3D genome methods -
 
HiCDB: a sensitive and robust method for detecting contact domain boundaries
Chen, F.*, Li, G.*, Zhang, M. Q., & Chen, Y.
Nucleic acids research, 2018 [Paper][RCode][MatlabCode]
- 3D genome in differention and disease -
 
MyoD is a 3D genome structure organizer for muscle cell identity
Wang, R.*, Chen, F.*, Chen, Q.*, Wan, X.*, … & Zhu, D.
Nature communications, 2022 [Paper]
 
3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia.
Yang, L.*, Chen, F.*, Zhu, H.*, Chen, Y., … & Wu, H.
Nature communications, 2021 [Paper]

📝 Publications

  1. Ji, S.#, Chen, F.#, Stein, P.#, Wang, J.#, Zhou, Z.#, Wang, L.#, … & Xie, W. (2023). OBOX regulates murine zygotic genome activation and early development. Nature. 2023 Aug;620(7976):1047-1053.
  2. Nie, X.#, Xu, Q.#, Xu, C.#, Chen, F.#, Wang, Q., Qin, D., … & Li, L. (2023). Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation. Nature communications, 14(1), 4275.
  3. Wang, R.#, Chen, F.#, Chen, Q.#, Wan, X.#, Shi, M., Chen, A. K., … & Zhu, D. (2022). MyoD is a 3D genome structure organizer for muscle cell identity. Nature communications, 13(1), 1-17. (IF: 17.694)
  4. Yang, L.#, Chen, F.#, Zhu, H.#, Chen, Y., Dong, B., Shi, M., … & Wu, H. (2021). 3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia. Nature communications, 12(1), 3708.
  5. Chen, F.#, Li, G.#, Zhang, M. Q., & Chen, Y. (2018). HiCDB: a sensitive and robust method for detecting contact domain boundaries. Nucleic acids research, 46(21), 11239-11250.
  6. Du, Z.#, Hu, L.#, Zou, Z.#, Liu, M.#, Li, Z., Lu, X., Harris, C., Xiang, Y., Chen, F., … & Xie, W. (2024). Stepwise de novo establishment of inactive X chromosome architecture in early development. Nature Genetics, 1-14.
  7. Li, L.#, Lai, F.#, Hu, X.#, Liu, B.#, …, Chen, F., Fan, Q., Ralston, A., & Xie, W. (2023). Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos. Science, 382(6676).
  8. Guo, T.#, Yuan, Z.#, Pan, Y., Wang, J., Chen, F., Zhang, M. Q. & Li, X. (2023). SPIRAL: integrating and aligning spatially resolved transcriptomics data across different experiments, conditions, and technologies. Genome biology, 24(1), 241. (IF: 12.3)
  9. Ye, Z., Chen, F., Zeng, J., Gao, J., & Zhang, M. Q. (2021). ScaffComb: A Phenotype‐Based Framework for Drug Combination Virtual Screening in Large‐Scale Chemical Datasets. Advanced Science, 8(24), 2102092. (IF: 17.521)
  10. Li, Y., He, Y., Liang, Z., Wang, Y., Chen, F., Djekidel, M. N., … & Gao, J. (2018). Alterations of specific chromatin conformation affect ATRA-induced leukemia cell differentiation. Cell death & disease, 9(2), 200. (IF: 9.696)
  11. Wang, J., Chen, F., Liu, L., Qi, C., Wang, B., Yan, X., … & Du, Y. (2016). Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation. Biomaterials, 91, 11-22. (IF: 15.304)

This website is regularly updated with our latest research activities and achievements.
Last updated: December 24, 2025