Fengling Chen, Ph.D

Principal Investigator
College of Biological Sciences
China Agricultural University

Education

2020.09~2024.09 Postdoctoral scholar

Department of Life Sciences, Tsinghua University, China

Supervisor: Prof. Wei Xie

2019.07~2020.01 Research Scholar

Department of Statistics, Stanford University, USA

Supervisor: Prof. Wing Hung Wong

2015.09~2020.08 Ph.D. Student

Department of Automation, Tsinghua University

Supervisor: Prof. Michael Zhang & Dr. Yang Chen

2011.09~2015.07 B.S.

Department of Electronic and Information Engineering

Beihang University, Beijing.

Experience

• 2020.12: invited talks at the 7th International Symposium on 3D Genomics, Beijing
• 2018.10: invited talks at the 5th International Symposium on 3D Genomics, Wuhan, Hubei
• 2017.09: top 10 winner out of 368 teams in Mobike Big Data Challenge 2017. View our solution at github.
• 2016.09 - 2017.01: Teaching assistant, Statistical Methods with Applications.

Select publications

1. Ji, S.#, Chen, F.#, Stein, P.#, Wang, J.#, Zhou, Z.#, Wang, L.#, … & Xie, W. (2023). OBOX regulates murine zygotic genome activation and early development. Nature. 2023 Aug;620(7976):1047-1053.
2. Nie, X.#, Xu, Q.#, Xu, C.#, Chen, F.#, Wang, Q., Qin, D., … & Li, L. (2023). Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation. Nature communications, 14(1), 4275.
3. Wang, R.#, Chen, F.#, Chen, Q.#, Wan, X.#, Shi, M., Chen, A. K., … & Zhu, D. (2022). MyoD is a 3D genome structure organizer for muscle cell identity. Nature communications, 13(1), 1-17. (IF: 17.694)
4. Yang, L.#, Chen, F.#, Zhu, H.#, Chen, Y., Dong, B., Shi, M., … & Wu, H. (2021). 3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia. Nature communications, 12(1), 3708.
5. Chen, F.#, Li, G.#, Zhang, M. Q., & Chen, Y. (2018). HiCDB: a sensitive and robust method for detecting contact domain boundaries. Nucleic acids research, 46(21), 11239-11250.
6. Du, Z.#, Hu, L.#, Zou, Z.#, Liu, M.#, Li, Z., Lu, X., Harris, C., Xiang, Y., Chen, F., … & Xie, W. (2024). Stepwise de novo establishment of inactive X chromosome architecture in early development. Nature Genetics, 1-14.
7. Li, L.#, Lai, F.#, Hu, X.#, Liu, B.#, …, Chen, F., Fan, Q., Ralston, A., & Xie, W. (2023). Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos. Science, 382(6676).
8. Guo, T.#, Yuan, Z.#, Pan, Y., Wang, J., Chen, F., Zhang, M. Q. & Li, X. (2023). SPIRAL: integrating and aligning spatially resolved transcriptomics data across different experiments, conditions, and technologies. Genome biology, 24(1), 241. (IF: 12.3)
9. Ye, Z., Chen, F., Zeng, J., Gao, J., & Zhang, M. Q. (2021). ScaffComb: A Phenotype‐Based Framework for Drug Combination Virtual Screening in Large‐Scale Chemical Datasets. Advanced Science, 8(24), 2102092. (IF: 17.521)
10. Li, Y., He, Y., Liang, Z., Wang, Y., Chen, F., Djekidel, M. N., … & Gao, J. (2018). Alterations of specific chromatin conformation affect ATRA-induced leukemia cell differentiation. Cell death & disease, 9(2), 200. (IF: 9.696)
11. Wang, J., Chen, F., Liu, L., Qi, C., Wang, B., Yan, X., … & Du, Y. (2016). Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation. Biomaterials, 91, 11-22. (IF: 15.304)

Contact

E-mail:cfl24@cau.edu.cn

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